Highly Enantioselectiv Copper-catalyzed Allylic Alkylation With Phosphoramidite Ligands

New phosphoramidites were applied as chiral ligands in the Cu-catalyzed allylic alkylation with dialkylzinc reagents.A variety of substrates, reagents and chiral ligands were screened,resulting in improved catalytic methodology for allylic bromides in which enantioselectivities up to 88%were reached.

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